Dr. Raimund Nagel

Dr. Raimund Nagel


Room: 104

Phone: 0341-9738524


Education and Appointments

Since 2019Group leader in the department of Prof. Severin Sasso at the University of Leipzig (Germany)
2014-2019Postdoctoral Researcher in the group of Prof. Reuben Peters at the Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, (USA), funded by Deutsche Forschungsgemeinschaft (2016 – 2018)
2010-2014Ph.D. student and postdoctoral fellow at the Max-Planck-Institute for Chemical Ecology in the Biochemistry Department of Prof. Jonathan Gershenzon
2004-2010Undergraduate studies in biochemistry at the Friedrich-Schiller-Universität Jena (Germany)

Selected Publications

Nagel R2) (2019) Pyrethrin biosynthesis: From a phytohormone to specialized metabolite. Plant Physiology 181:836–837 (Commentary)

Lackus ND, Petersen NP, Nagel R, Schmidt A, Irmisch S, Gershenzon J, Köllner TG (2019) Identification and characterization of trans-Isopentenyl diphosphate synthases involved in herbivory-induced volatile terpene formation in Populus trichocarpa. Molecules 24:2408

Nagel R2), Schmidt A, Peters RJ (2019) Isoprenyl diphosphate synthases: the chain length determining step in terpene biosynthesis. Planta 249:9–20 (Review)

Nagel R, Bieber JE, Schmidt-Dannert MG, Nett RS, Peters RJ (2018) A third class: Functional gibberellin biosynthetic operon in beta-Proteobacteria. Front. Microbiol. 2916(9)

Nagel R, Peters R (2018) Probing the specificity of CYP112 in bacterial gibberellin biosynthesis. Biochemical Journal 475:2167-2177

Nagel R, Peters RJ (2018) Diverging Mechanisms: Cytochrome-P450-catalyzed demethylation and γ-lactone formation in bacterial gibberellin biosynthesis. Angewandte Chemie 130:6190–6193

Nagel R, Thomas JA, Adekunle FA, Mann FM, Peters RJ (2018) Arginine in the FARM and SARM: A role in chain-length determination for arginine in the aspartate-rich motifs of isoprenyl diphosphate synthases from Mycobacterium tuberculosis. Molecules 23:2546

Nagel R, J. Peters R (2017) 18O2 labeling experiments illuminate the oxidation of ent-kaurene in bacterial gibberellin biosynthesis. Organic & Biomolecular Chemistry 15:7566–7571

Nagel R, Peters RJ (2017) Investigating the phylogenetic range of gibberellin biosynthesis in bacteria. MPMI 30:343–349

Nagel R1), Turrini PCG1), Nett RS, Leach JE, Verdier V, Sluys M-AV, Peters RJ (2017) An operon for production of bioactive gibberellin A4 phytohormone with wide distribution in the bacterial rice leaf streak pathogen Xanthomonas oryzae pv. oryzicola. New Phytologist 214:1260–1266

Nett RS, Montanares M, Marcassa A, Lu X, Nagel R, Charles TC, Hedden P, Rojas MC, Peters RJ (2017) Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution. Nat Chem Biol 13:69–74

Beran F, Rahfeld P, Luck K, Nagel R, Vogel H, Wielsch N, Irmisch S, Ramasamy S, Gershenzon J, Heckel DG, Köllner TG (2016) Novel family of terpene synthases evolved from trans-isoprenyl diphosphate synthases in a flea beetle. PNAS 113:2922–2927

Kortbeek RWJ, Xu J, Ramirez A, Spyropoulou E, Diergaarde P, Otten-Bruggeman I, de Both M, Nagel R, Schmidt A, Schuurink RC, Bleeker PM (2016) Engineering of tomato glandular trichomes for the production of specialized metabolites. In: O’Connor SE, editor(s). Methods in Enzymology. Academic Press; 2016. p. 305–331

Nagel R, Bernholz C, Vranová E, Košuth J, Bergau N, Ludwig S, Wessjohann L, Gershenzon J, Tissier A, Schmidt A (2015) Arabidopsis thaliana isoprenyl diphosphate synthases produce the C25 intermediate geranylfarnesyl diphosphate. The Plant Journal 84:847–859 (Journal Cover)

Nagel R, Berasategui A, Paetz C, Gershenzon J, Schmidt A (2014) Overexpression of an isoprenyl diphosphate synthase in Spruce leads to unexpected terpene diversion products that function in plant defense. Plant Physiology 164:555–569

Frick S, Nagel R, Schmidt A, Bodemann RR, Rahfeld P, Pauls G, Brandt W, Gershenzon J, Boland W, Burse A (2013) Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway. PNAS 110:4194–4199

Kulkarni R, Pandit S, Chidley H, Nagel R, Schmidt A, Gershenzon J, Pujari K, Giri A, Gupta V (2013) Characterization of three novel isoprenyl diphosphate synthases from the terpenoid rich mango fruit. Plant Physiology and Biochemistry 71:121–131

Nagel R, Gershenzon J, Schmidt A (2012) Nonradioactive assay for detecting isoprenyl diphosphate synthase activity in crude plant extracts using liquid chromatography coupled with tandem mass spectrometry. Analytical Biochemistry 422:33–38

Schmidt A, Nagel R, Krekling T, Christiansen E, Gershenzon J, Krokene P (2011) Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies). Plant Mol Biol 77:577–590  

1) equal contributions
2) corresponding authorship

last modified: 21.11.2019