Prof. Dr. Severin Sasso

Prof. Dr. Severin Sasso

Head of Department

Room: 106

Phone: 0341-9736893


Education and Appointments

Since 2019Full Professor (W3) of Plant Physiology at the University of Leipzig (Germany),
Faculty member of the Collaborative Research Centre Chemical Mediators in Complex Biosystems (SFB 1127) (since 2014)
2017-2019 Independent principal investigator (Akademischer Rat) at the Friedrich Schiller University Jena
2011-2017Junior Professor (Assistant Professor) of Molecular Botany at the Friedrich-Schiller-University Jena
2010-2011Postdoctoral fellow in the laboratories of Prof. Christian Hertweck at the Leibniz Institute for Natural Product Research and Infection Biology (HKI) and Prof. Maria Mittag at the Friedrich Schiller University, Jena
2007-2010Postdoctoral fellow in the laboratory of Prof. Alison Smith at the Department of Plant Sciences, University of Cambridge (UK)
2002-2007Ph.D. student and postdoctoral fellow in the laboratories of Prof. Peter Kast and Prof. Donald Hilvert at the ETH Zürich (Switzerland)
1997-2002Undergraduate student in chemistry at the ETH Zürich

Selected Publications

Sasso S, Stibor H, Mittag M, Grossman AR (2018) From molecular manipulation of domesticated Chlamydomonas reinhardtii to survival in nature. eLife 7, e39233 (Review)

Heimerl N1), Hommel E1), Westermann M, Meichsner D, Lohr M, Hertweck C, Grossman AR, Mittag M, Sasso S (2018) A giant type I polyketide synthase participates in zygospore maturation in Chlamydomonas reinhardtii. The Plant Journal 95:268–281

Aiyar P, Schaeme D, García-Altares M, Flores DC, Dathe H, Hertweck C, Sasso S2), Mittag M2) (2017) Antagonistic bacteria disrupt calcium homeostasis and immobilize algal cells. Nat Commun 8:1–13

Hirth M, Liverani S, Mahlow S, Bouget FY, Pohnert G, Sasso S (2017) Metabolic profiling identifies trehalose as an abundant and diurnally fluctuating metabolite in the microalga Ostreococcus tauri. Metabolomics 13:68

Müller N, Wenzel S, Zou Y, Künzel S, Sasso S, Weiß D, Prager K, Grossman A, Kottke T, Mittag M (2017) A plant cryptochrome controls key features of the Chlamydomonas circadian clock and its life cycle. Plant Physiology 174:185–201

Helliwell KE, Lawrence AD, Holzer A, Kudahl UJ, Sasso S, Kräutler B, Scanlan DJ, Warren MJ, Smith AG (2016) Cyanobacteria and eukaryotic algae use different chemical variants of vitamin B12. Current Biology 26:999–1008

Shelest E, Heimerl N, Fichtner M, Sasso S (2015) Multimodular type I polyketide synthases in algae evolve by module duplications and displacement of AT domains in trans. BMC Genomics 16:1015

Hom EFY, Aiyar P, Schaeme D, Mittag M, Sasso S (2015) A chemical perspective on microalgal–microbial interactions. Trends in Plant Science 20:689–693 (Review)

Helliwell KE, Scaife MA, Sasso S, Araujo APU, Purton S, Smith AG (2014) Unraveling vitamin B12-responsive gene regulation in algae. Plant Physiology 165:388–397

Sasso S, Shelest E, Hoffmeister D (2014) Comments on the distribution and phylogeny of type I polyketide synthases and nonribosomal peptide synthetases in eukaryotes. PNAS 111:E3946–E3946 (Commentary)

Sasso S, Pohnert G, Lohr M, Mittag M, Hertweck C (2012) Microalgae in the postgenomic era: a blooming reservoir for new natural products. FEMS Microbiol Rev 36:761–785 (Addendum: FEMS Microbiol. Rev. 37, 284 (2013)) (Review)

Beel B, Prager K, Spexard M, Sasso S, Weiss D, Müller N, Heinnickel M, Dewez D, Ikoma D, Grossman AR, Kottke T, Mittag M (2012) A flavin binding cryptochrome photoreceptor responds to both blue and red light in Chlamydomonas reinhardtii. The Plant Cell 24:2992–3008

Kazamia E, Czesnick H, Nguyen TTV, Croft MT, Sherwood E, Sasso S, Hodson SJ, Warren MJ, Smith AG (2012) Mutualistic interactions between vitamin B12-dependent algae and heterotrophic bacteria exhibit regulation. Environmental Microbiology 14:1466–1476

Sasso S1), Ökvist M1),Roderer K, Gamper M, Codoni G, Krengel U, Kast P (2009) Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner. The EMBO Journal 28:2128–2142

Sasso S, Ramakrishnan C, Gamper M, Hilvert D, Kast P (2005) Characterization of the secreted chorismate mutase from the pathogen Mycobacterium tuberculosis. The FEBS Journal 272:375–389

1) equal contributions
2) shared corresponding authorship

last modified: 04.12.2019